IMPACTS OF HUMANIZED MOUSE MODELS ON THE INVESTIGATION OF HIV-1 INFECTION: ILLUMINATING THE ROLES OF VIRAL ACCESSORY PROTEINS IN VIVO

Human immunodeficiency virus type 1 (HIV-1) encodes four accessory genes: vif, vpu, vpr, and nef.Recent investigations using in vitro cell culture systems have shed light on the roles of these HIV-1 accessory proteins, Vif, Vpr, Vpu, and Nef, in counteracting, modulating, and evading various cellular factors that are responsible for anti-HIV-1 intr

In the current manuscript, we describe the reactivity of a series of iridium(III) pincer complexes with the general formulae [(PEP)IrCl(CO)(H)]n (n = +1, +2) towards base, where PEP is a pincer-type ligand with different central donor groups, and E is the ligating atom of this group (E = B, C, N).The donor groups encompass a secondary amine, a phos

Abstract The cryo-electron microscopy (cryoEM) method has enabled high-resolution structure determination of numerous biomolecules and complexes.Nevertheless, cryoEM sample preparation of challenging proteins and complexes, especially those with low abundance or with preferential orientation, remains a major hurdle.We developed an affinity-grid met

Jaehyeon Park, 1,* Hyungsuk Kim, 1, 2,* Mi-Yeon Song 1 1Department of Korean Rehabilitation Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea; 2Department of Korean Rehabilitation Medicine, Kyung Hee Bronc Flank Strap University Medical Center, Seoul, Republic of Korea*These authors contributed equally to this wor